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By elevating these catecholamines, experts hypothesize that the drug may have an impact on the brain's leptin levels. Phentermine is believed to raise the brain's leptin levels.
The elevation of catecholamines is also believed to halt the chemical messenger neuropeptide Y, a peptide responsible for increasing hunger and fat storage.
Phentermine primarily works to reduce obesity by reducing the body's hunger perception. This is mainly done through a cognitive process by working on several nuclei in the hypothalamus section of the brain.
The drug also works outside the brain by releasing adrenaline and noradrenaline to ensure that fat cells break down stored fat in the body.
Ideally, phentermine should be consumed in the morning an hour or two before the first meal of the day. Never consume phentermine in the evening or especially after a meal.
Patients are advised to not consume phentermine in the evening due to the possibility of insomnia. Phentermine is normally available orally.
It is available in orally dissolving capsules and tablets in a wide range of strengths, often based on the brand. Consumption of phentermine by any other form is ill advised.
Suprenza is an example of an orally disintegrating form of phentermine. Patients who consume suprenza must allow the drug to simply dissolve on their tongues.
Different brands or labels of phentermine have different administration periods. Most brands require you to take the drug before breakfast on an empty stomach, while there are some brands that recommend consumption between breakfast and lunch.
Never consume phentermine or any of its combinations in tandem with alcohol as the side effects of the drug is likely be extra harmful when the body is forced to break down alcohol and phentermine together.
You should avoid any medication that has the potential to dull the nervous system, like alcohol does, when taking phentermine.
As phentermine stimulates the nervous system and alcohol inhibits it, the two work to cancel each other out and prevent the desired effects of phentermine from bearing fruit.
This is in fact a bigger problem with alcohol consumption than any possible side effects. If you are being administered monoamine oxidase inhibitors, do not, under any circumstances, consume phentermine concurrently.
Patients should wait for a period of 14 days after completing their consumption of monoamine oxidase inhibitors to begin their consumption of phentermine.
If you find yourself developing a tolerance for your phentermine medication , do not start exceeding your recommended dosage. Instead, you should stop consuming phentermine and ask your physician to prescribe another weight loss drug.
Alternatively, you can stop using phentermine for a couple of months which should remove your tolerance for the anorectic.
Despite the fact that phentermine in its current forms has no minimum administration period, the medication should ideally not be taken for more than weeks at a stretch as it can lead to serious long-term consequences if it's present in the body for a lengthy period of time.
When you are using phentermine, make sure that you store the drug at room temperature. Keeping it away from heat and moisture is of utmost importance.
People who engage in potentially dangerous activities on a daily basis such as operating heavy machinery must take extra caution.
If you are suffering from diabetes mellitus and taking medication, it is advisable to reduce the level of your oral hypoglycemic or insulin medication in a controlled manner before starting your course of phentermine.
Experts specify that certain types of people should not be prescribed phentermine because of its contraindication properties.
Specifically, its use can be contraindicated in people who have glaucoma, a history of drug abuse, hyperthyroidism, a history of cardiovascular disease, and hypersensitivity.
Individuals who are currently taking another form of amphetamine medicine such as adderall are also advised against consuming phentermine. Pregnant women, women who are planning on becoming pregnant or those who are breast-feeding are also discouraged from using phentermine.
This is because phentermine will pass through the breast milk of a woman who is breast feeding and directly to her baby.
The effects of phentermine on small children are unknown as there have been almost no instances of such cases, but it is highly reasonable to assume that it will not end well for babies.
This is remarkable for a drug that has had huge question marks about its side effects on the human body. So how exactly has it always been so popular?
Phentermine and phentermine hydrochloride gained popularity as being short-term cures to obesity. In the twentieth century, phentermine was one of the very few weight loss drugs available in the market.
The price of phentermine has always been low when compared to its competitors, some of them that have way fewer side effects.
Other diet drugs such as Xenical and Meridia are priced significantly higher than phentermine. There have been numerous allegations over the last fifty years that physicians have directly and indirectly benefited from prescribing phentermine and its various combinations to money conscious patients.
However, this is nothing out of the ordinary when it comes to prescription drugs as pharmaceutical companies have time and again been accused of these practices.
Phentermine's popularity is also historically linked with the popularity of fenfluramine. When fenfluramine was developed in the s, the drug was expected to become a market leader in the segment.
However, this was vastly different from the ground reality. Most patients who consumed fenfluramine complained of effects such as anxiety and nausea on a large scale basis.
American Home Products manufactured the drug under the name Pondimin, but the market sales were extremely poor and it never caught on as a suitable alternative to regular exercise and dieting.
In , researchers at the University of Rochestor stated that the combination of phentermine and fenfluramine was incredibly effective as an obesity combatant.
The research team, led by Dr. Micheal Weintraub, believed that this combination did not cause the same irritating side effects that other diet drugs did.
This led to a huge surge in the popularity and sales of phentermine. Fen-Phen was highly successful in the market as there were cases in which patients were able to drop as much as 30 pounds in a couple of months.
As the popularity of Fen-Phen soared, American Home Products was worried as the patent the company held for Pondimin was about to expire.
The company was against the idea of its competitors getting their hands on fenfluramine and the burgeoning profits of Fen-Phen.
American Home Products had to find a solution to this problem before their market share dipped. This problem was solved by the introduction of Redux to the market.
American Home Products and its subsidiaries developed a brand new version of fenfluramine, which happened to be known as dexfenfluramine.
The FDA was particularly wary about this new weight loss drug, but it approved the drug in after intensive debates about its potentially harmful effects.
The introduction of Dexfen-Phen reinvigorated the market, and it was thought to be even better than Fen-Phen when it came to fighting obesity.
Just like the fenfluramine and phentermine combine, Dexfen-Phen was not intensively tested for safety. The company's focus at this time was to ensure that the FDA would approve its new product before the patent on fenfluramine ran out.
As such, it was not highly preoccupied with the adverse effects of dexfenfluramine on the people who consumed it.
As the sales of Dexfen-Phen were rising in , multiple reports of its adverse effects and its links to coronary heart disease surfaced and a few patients consuming the medication ended up dead, including some patients who had a history of clean health.
The FDA could no longer sit idle and it banned the commercial distribution of dexfenfluramine and fenfluramine. Phentermine has multiple side effects that have come to the fore in various ways over the years.
Phentermine's contentious history has time and again led to numerous experts to call for its removal from the market, but the drug has managed to stay in distribution thanks to a number of factors.
Some of the side effects of phentermine include severe chest pain, decreased energy levels, dizziness and fainting, irregular and rapid heartbeat, swelling and trembling of the feet, thought impairment, headaches, and numbness of the arms and legs.
The effects also include restlessness, euphoria, hypertension, diarrhea, dry mouth, facial oedema, impotence, urticaria, and arrhythmia. Phentermine has been known to have various gastrointestinal effects on the body.
This primarily includes vomiting and cramps. Acute transient ischaemic colitis has also been linked to regular intake of phentermine. The dermatological effects of the drug include pale skin and drying of the mucous membrane.
The drug also has notable genitourinary effects. Acute urinary retention is a common symptom. Renal ischemia is possible, and renal failure can also occur in tandem with dehydration and rhabdomolysis.